Glucocorticoids reduce renal NHE8 expression
نویسندگان
چکیده
منابع مشابه
Glucocorticoids reduce renal NHE8 expression
The proximal tubule reabsorbs most of the filtered bicarbonate which is mediated in large part by Na+/H+ exchange (NHE). We have previously demonstrated that there is an isoform switch during postnatal maturation from NHE8 to NHE3 that is concordant with the postnatal increase in serum glucocorticoid levels. To examine if glucocorticoids may be responsible for this isoform switch, we administer...
متن کاملTranscriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5.
Sodium/hydrogen exchangers (NHEs) are a family of proteins that transport sodium ions into the cells by moving protons out of the cells. They play a major role in sodium absorption, cell volume regulation, and intracellular pH regulation. Three out of nine identified NHEs (NHE2, NHE3, and NHE8) are expressed on the apical membrane of intestinal epithelial cells. Glucocorticoids have been found ...
متن کاملRenal expression of novel Na+/H+ exchanger isoform NHE8.
Although Na(+)/H(+) exchanger isoform 3 (NHE3) mediates most Na(+)/H(+) exchange in the proximal tubule, studies of NHE3/NHE2 null mice suggest residual Na(+)-dependent proton secretion (Choi JY, Shah M, Lee MG, Schultheis PJ, Shull GE, Muallem S, and Baum M. J Clin Invest 105: 1141-1146, 2000). To characterize additional NHE isoforms that might be expressed in the kidney, we identified the par...
متن کاملRenal NHE expression and activity in neonatal NHE3- and NHE8-null mice.
Na(+)/H(+) exchanger (NHE)3 is the predominant NHE on the brush-border membrane of the proximal tubule in adult animals. NHE8 has been localized to the brush-border membrane of proximal tubules and is more highly expressed in neonates than in adult animals. However, the relative role of NHE8 in neonatal renal acidification is unclear. The present study examined if there was a compensatory incre...
متن کاملEffect of thyroid hormone on the postnatal renal expression of NHE8.
We previously demonstrated that there are developmental changes in proximal tubule Na(+)/H(+) exchanger (NHE) activity. There is a maturational increase in postnatal brush-border membrane (BBM) vesicle NHE3 protein abundance and decrease in NHE8 protein abundance. The purpose of this study was to determine whether thyroid hormone plays a role in the rat renal maturational isoform switch from NH...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2013
ISSN: 2051-817X
DOI: 10.1002/phy2.31